Monthly Archives: August 2015

Cruisin’ to End MS

Today is the 7th Annual Cruisin’ to End MS day – come celebrate with A&W Food Services of Canada Inc. to support Canadians living with MS. Just today, one dollar from every Teen Burger purchased at any of the 840 A&W restaurants around Canada will go towards the MS Society of Canada. Alternatively, you can buy $1, $2 or $5 paper cutouts, give through in-store donation mugs or make online donations at cruisintoendms.ca.

On top of government advocacy, financial support and wellness programs for people affected by MS, the money raised from this event goes a long way to supporting crucial MS research into disease mechanisms, risk factors, therapies, and symptom management and quality of life. Click here to read about the research we fund through your generous donations.

What does wellness mean to you?

Photo credit: distelfliege

Image credits: distelfliege / Flickr Creative Commons

The MS Society recognizes the importance of, and need to, fund research that is focused on wellness, such as:

  • the impact of physical activity on MS symptoms
  • the role of diet in terms of causation, treatment and/or prevention of MS
  • the emotional and mental effects of MS

But what should be the priorities in wellness research be? What outcomes should the research we fund lead to? We need you to help inform these questions and voice your opinion based on your personal experiences with MS.

What matters most to you in terms of wellness? What do you want to learn more about? What do you think is necessary to improve wellness in MS? Share your feedback by responding to our Wellness Survey and help shape the future of research! Follow the conversation on Twitter and share your thoughts using hashtag #WellnessMS!

On behalf of the MS Society I thank you and look forward to reading your responses!

Research Decoder: Outcome measures I – Clinical

hClinical trials are an indispensable part of the process that determines which disease-treating interventions (including drugs, procedures, technologies, or lifestyle modifications) can move from the experimental stage to the public realm. Health care decision makers that establish health policy, such as the approval of new drugs or repurposing existing drugs for new indications, rely on the findings of clinical trials about the safety and effectiveness of an intervention since they provide some of the most reliable evidence of the value of an intervention. But how do the investigators who conduct the trials determine whether an intervention really works?

When designing a clinical trial, research investigators chose appropriate outcome measures, or endpoints, that they will monitor in order to determine the effectiveness of the intervention they are studying. Outcome measures come in a variety of forms, and can be either objective (such as the results of a laboratory test), subjective (such as a participant’s perception of their fatigue) or oftentimes a combination of the two. They can also be classified as primary or secondary. Primary endpoints measure outcomes that answer the key question being asked by the trial, and the number of participants enrolled in the trial is chosen in order to have enough statistical power to detect differences in this primary measure. Secondary endpoints capture measures that, although not as imperative as the primary endpoint, are still relevant to the study and can sometimes even lead to follow-up trials in which investigators have the chance to fine-tune the outcome measures and study design.

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